Modern Pathology 2019 September iv [Link]
Marchevsky AM, Khoor A, Walts AE, Nicholson AG, Zhang YZ, Roggli V, Carney J, Roden AC, Tazelaar HD, Larsen BT, LeStang N, Chirieac LR, Klebe S, Tsao MS, De Perrot M, Pierre A, Hwang DM, Hung YP, Mino-Kenudson M, Travis W, Sauter J, Beasley MB, Galateau-Sallé F
Localized malignant mesotheliomas (LMM) is an uncommon in addition to poorly recognized neoplasm. Its pathologic diagnosis is oft surprising inward patients alongside serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or principal sarcomas. Once a tumor is diagnosed every bit “mesothelioma”, LMM is oft false for diffuse malignant mesothelioma (DMM). Best currently available bear witness close LMM was collected from the literature in addition to cases diagnosed past times members of the International Mesothelioma Panel (IMP). One hundred in addition to 1 (101) LMM induce got been reported inward the English linguistic communication literature. Patients had localized tumors alongside identical histopathologic features to DMM. Patients ranged inward historic menstruation from six to 82 years; 75% were men. Most (82%) of the tumors were intrathoracic. Others presented every bit intrahepatic, mesenteric, gastric, pancreatic, umbilical, splenic, in addition to abdominal wall lesions. Tumors varied inward size from 0.6 to 15 cm. Most patients underwent surgical resection and/or chemotherapy or radiations therapy. Median survival inward a subset of patients was 29 months. Seventy 2 additional LMM from IMP institutions ranged inward historic menstruation from 28 to 95 years; 58.3% were men. Sixty tumors (83.3%) were intrathoracic, others presented inward intraabdominal sites. Tumors varied inward size from 1.2 to 19 cm. Median survival for 51 cases was 134 months. Best bear witness was used to formulate guidelines for the diagnosis of LMM. It is of import to distinguish LMM from DMM every bit their handling in addition to prognosis is different. Influenza A virus subtype H5N1 multidisciplinary approach is needed for the diagnosis of LMM every bit it shows identical histopathology in addition to immunophenotype to DMM.
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