Journey of the American Society of Cytopathology 2019 August viii [Link]
Siddiqui MT, Schmitt F, Churg A
We alive inward the “era” of minimally invasive procedures, molecular testing, together with personalized care. Effusions accept a high sensitivity together with volition oft yield diagnostic cytological material. The companion session presented past times the American Society of Cytopathology at the 2019 United States together with Canadian Academy of Pathology coming together outlined our electrical current together with hereafter projected practices inward characterizing, managing, together with diagnosing serous cavity fluids. In this minute part, the purpose of theranostics together with the diagnosis of malignant mesothelioma, equally was discussed at the meeting, accept been highlighted. In theranostics, a vast total of information has been reported regarding the epidermal increment component receptor together with related molecules. Some studies accept besides reported on HER2 immunohistochemistry together with fluorescence inward situ hybridization. This follows the near active areas of enquiry inward targeted therapy. Furthermore, during this session, malignant mesothelioma was extensively discussed. The cytologic diagnosis of malignant mesothelioma inward effusion specimens has been controversial; however, a definitive diagnosis volition hold upward possible inward many cases. Radiologic information should hold upward sought, because the radiologist tin oft render a definite or really probable diagnosis of malignancy. Microscopically, high cellularity and/or numerous balls of cells or papillary groups volition favor the diagnosis of mesothelioma. It is of import to exclude metastatic carcinoma amongst a broad-spectrum carcinoma marker, of which claudin-4 has been the best, because it volition non cross react amongst mesothelioma. BAP1 together with MTAP immunohistochemistry together with CDKN2A fluorescence inward situ hybridization are really useful adjunctive techniques for separating benign from malignant mesothelial proliferations. The exercise of ii of these approaches together volition orbit a sensitivity of 80% to 90% for epithelial mesotheliomas inward the pleura, although the sensitivity has been lower inward the peritoneal cavity.
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