Mesotip: Stage Two Multicenter Randomized Case Evaluating The Association Of Pipac Together With Systemic Chemotherapy Vs. Systemic Chemotherapy Solitary Equally 1St-Line Handling Of Malignant Peritoneal Mesothelioma.

Pleura in addition to Peritoneum 2019 June 27 [Link]

Sgarbura O, Gourgou S, Tosi D, Bakrin N, Bouazza N, Delaine S, De Forges H, Pocard M, Quénet F

Abstract

BACKGROUND:

Malignant peritoneal mesothelioma (MPM) is a rare tumoral illness characterized yesteryear the diffuse interest of the peritoneal serosa. The measure frontline handling of MPM is cytoreductive surgical operation amongst hyperthermic intraperitoneal chemotherapy (HIPEC) unless the peritoneal illness is considered unresectable. For unresectable patients the measure frontline handling is a combination of cisplatin in addition to pemetrexed only the prognosis remains ominous amongst exclusively xiii months of overall survival (OS).

METHODS:

The proposed report is a multicenter randomized non-comparative report evaluating the association of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) in addition to systemic chemotherapy vs. systemic chemotherapy lone equally first-line handling of MPM. Patients volition endure randomized amongst a 2:1 ratio using a minimization technique. Sixty-six patients accept to endure enrolled. Stratification volition endure performed according to histology (epithelioid vs. sarcomatoid in addition to biphasic), presence of extraperitoneal illness in addition to center. Primary objective is OS in addition to secondary objectives include progression-free survival (PFS), safety, compliance, feasibility, conversion to resectability, histological reply to handling in addition to character of life.

CONCLUSIONS:

We await to present that intensification of the starting fourth dimension business handling amongst PIPAC for initially unresectable MPM patients increases OS.



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