Clinicopathologic Report Of Deciduoid Mesothelioma Using Smarcb1/Ini1 Immunohistochemistry As Well As Fluorescence Inward Situ Hybridization.

Human Pathology 2019 August 22 [Link]

Kawai T, Ogata S, Nakashima H, Urabe S, Murakami I, Hiroshima K

Abstract

Deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. Malignant rhabdoid tumors, renal medullary carcinoma, together with about synovial sarcomas present a loss of SMARCB1/INI1 protein, a fellow member of the SWI/SNF chromatin-remodeling complex. All of those tumors are known to convey rhabdoid cells. Some mesothelioma cases, such equally those of the deciduoid type, convey equally good been reported to possess such rhabdoid features. Since this theme has non been studied inwards malignant mesothelioma, nosotros analyzed the immunohistochemical facial expression of SMARCB1/INI1 inwards malignant mesotheliomas [45 epithelioid type (including nine deciduoid type), 12 biphasic type, together with 17 sarcomatoid type]. We employed (a) SMARCB1/INI1 immunohistochemistry, using an antibody to the INI1 cistron production together with (b) Fisher’s exact test, Logistic regression analysis, the Kaplan-Meier method, together with the Wilcoxon exam for survival analysis for prognostic component subdivision evaluation (SAS 9.4). The results showed that 17 of 74 (23%) malignant mesothelioma cases (epithelioid: 24%; biphasic; 8%; sarcomatoid; 29%) had reduced SMARCB1/INI1 expression. Reduced SMARCB1/INI1 facial expression appeared to hold upwardly to a greater extent than frequent inwards the deciduoid type (67%), of which at that spot were admittedly solely a few cases, than inwards either the epithelioid type (14%) or biphasic type (8%), whether or non rhabdoid cells were present, only non dissimilar betwixt the deciduoid together with sarcomatoid types. However, at that spot was no statistically pregnant divergence inwards prognosis betwixt malignant mesotheliomas amongst reduced versus preserved SMARCB1/INI1 poly peptide expression. The results advise that inwards differential diagnosis, cases amongst reduced SMARCB1/INI1 poly peptide facial expression should non hold upwardly excluded from a diagnosis of malignant mesothelioma.



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