Modern Pathology 2019 August five [Link]
Wronkiewicz SK, Roggli VL, Hinrichs BH, Kendler A, Butler RA, Christensen BC, Marsit CJ, Nelson HH, McClean MD, Kelsey KT, Langevin SM
Asbestos describes a grouping of naturally occurring fibrous silicate mineral compounds that convey been associated alongside a number of respiratory maladies, including mesothelioma together with lung cancer. In addition, based primarily on epidemiologic studies, asbestos has been implicated every bit a adventure element for laryngeal together with pharyngeal squamous jail cellular telephone carcinoma (SCC). The master copy objective of this function was to strengthen existing bear witness via empirical demonstration of persistent asbestos fibers embedded inwards the tissue surrounding laryngeal together with pharyngeal SCC, so providing a to a greater extent than definitive biological link betwixt exposure together with disease. Six human papillomavirus (HPV)-negative laryngeal (n = 4) together with pharyngeal (n = 2) SCC cases alongside a history working inwards an asbestos-exposed draw were selected from a large population-based case-control report of caput together with cervix cancer. H5N1 laryngeal SCC illustration alongside no history of occupational asbestos exposure was included every bit a control. Tissue cores were obtained from following nonneoplastic tissue inwards tumor blocks from the initial primary tumor resection, together with mineral fiber analysis was performed using a scanning electron microscope equipped alongside an release energy dispersive X-ray analyzer (EDXA). Chrysotile asbestos fiber bundles were identified inwards 3/6 of evaluated cases alongside a history of occupational asbestos exposure. All 3 cases had tumors originating inwards the larynx. In addition, a wollastonite fiber of unclear significance was identified ane of the HPV-negative pharyngeal SCC cases. No mineral fibers were identified inwards following tissue of the illustration without occupational exposure. The presence of asbestos fibers inwards the epithelial tissue surrounding laryngeal SCC inwards cases alongside a history of occupational asbestos exposure adds a telephone commutation draw of physical bear witness implicating asbestos every bit an etiologic factor.
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